hot-spot mutations Search Results


tumor cell lines human gastric cancer cell line mkn 45  (ATCC)
91
ATCC tumor cell lines human gastric cancer cell line mkn 45
Tumor Cell Lines Human Gastric Cancer Cell Line Mkn 45, supplied by ATCC, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human colorectal carcinoma cells hct 116 tcp1006  (ATCC)
91
ATCC human colorectal carcinoma cells hct 116 tcp1006
Human Colorectal Carcinoma Cells Hct 116 Tcp1006, supplied by ATCC, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 91 stars, based on 1 article reviews
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atcc validated lung cancer cell lines  (ATCC)
90
ATCC atcc validated lung cancer cell lines
Atcc Validated Lung Cancer Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
atcc validated lung cancer cell lines - by Bioz Stars, 2026-10
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breast cancer p53 hotspot mutation cell panel  (ATCC)
93
ATCC breast cancer p53 hotspot mutation cell panel
Breast Cancer P53 Hotspot Mutation Cell Panel, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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hot-spot kif5a mutations  (Inherited Neuropathies Consortium)
90
Inherited Neuropathies Consortium hot-spot kif5a mutations
Hot Spot Kif5a Mutations, supplied by Inherited Neuropathies Consortium, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hot-spot+mutations/hot+spot+kif5a+mutations/10__3233_slash_jnd___190427-367-46-28
Average 90 stars, based on 1 article reviews
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a mutational hotspot in braf structure  (Spacepac Industries)
90
Spacepac Industries a mutational hotspot in braf structure
Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational <t>hotspots</t> in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.
A Mutational Hotspot In Braf Structure, supplied by Spacepac Industries, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hot-spot+mutations/a+mutational+hotspot+in+braf+structure/pmc04227039-207-21-17
Average 90 stars, based on 1 article reviews
a mutational hotspot in braf structure - by Bioz Stars, 2026-10
90/100 stars
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targeted dna sequencing assay solid tumors hotspot mutations 48 genes  (ARUP Laboratories)
90
ARUP Laboratories targeted dna sequencing assay solid tumors hotspot mutations 48 genes
Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational <t>hotspots</t> in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.
Targeted Dna Sequencing Assay Solid Tumors Hotspot Mutations 48 Genes, supplied by ARUP Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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kras / nras / pik3ca / braf hot-spot mutations  (Sysmex Inostics)
90
Sysmex Inostics kras / nras / pik3ca / braf hot-spot mutations
Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational <t>hotspots</t> in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.
Kras / Nras / Pik3ca / Braf Hot Spot Mutations, supplied by Sysmex Inostics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hot-spot+mutations/kras+++nras+++pik3ca+++braf+hot+spot+mutations/pmc05471055-145-14-8
Average 90 stars, based on 1 article reviews
kras / nras / pik3ca / braf hot-spot mutations - by Bioz Stars, 2026-10
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cpg hotspot mutation  (Siemens AG)
90
Siemens AG cpg hotspot mutation
Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational <t>hotspots</t> in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.
Cpg Hotspot Mutation, supplied by Siemens AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hot-spot+mutations/cpg+hotspot+mutation/pm16250206-138-16-32
Average 90 stars, based on 1 article reviews
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hot-spot mutation region within the apc gene  (Kunkel GmbH)
90
Kunkel GmbH hot-spot mutation region within the apc gene
Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational <t>hotspots</t> in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.
Hot Spot Mutation Region Within The Apc Gene, supplied by Kunkel GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hot-spot+mutations/hot+spot+mutation+region+within+the+apc+gene/pm14961559-95-23-13
Average 90 stars, based on 1 article reviews
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krt1 and krt10 genes mutational hot spot analysis  (GeneDx Inc)
90
GeneDx Inc krt1 and krt10 genes mutational hot spot analysis
Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational <t>hotspots</t> in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.
Krt1 And Krt10 Genes Mutational Hot Spot Analysis, supplied by GeneDx Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hot-spot+mutations/krt1+and+krt10+genes+mutational+hot+spot+analysis/pm19689541-22-7-4
Average 90 stars, based on 1 article reviews
krt1 and krt10 genes mutational hot spot analysis - by Bioz Stars, 2026-10
90/100 stars
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mutational hot spot analysis  (GeneDx Inc)
90
GeneDx Inc mutational hot spot analysis
Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational <t>hotspots</t> in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.
Mutational Hot Spot Analysis, supplied by GeneDx Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hot-spot+mutations/mutational+hot+spot+analysis/pm19689541-22-9-4
Average 90 stars, based on 1 article reviews
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Image Search Results


Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational hotspots in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.

Journal: BMC Bioinformatics

Article Title: A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

doi: 10.1186/1471-2105-15-231

Figure Lengend Snippet: Statistic construction. In this example, we consider r ∈{3,9} and up to 3 potential mutational hotspots in the protein. First, μ and σ are calculated over each column. Next, we normalize each entry in the column by calculating Z i , s , r = X i , s , r − μ s , r σ s , r . We then take the maximum over each row to get Z 0 ,…, Z 1000 . The percentage of times Z 0 ≥ Z i , where i ∈{1,…,1000}, is the p-value of our observed statistic Z 0 . Note that if Z 0 is greater than Z i for all 1000 simulations, we report a p-value of <1.00 E-03.

Article Snippet: To illustrate this point we consider two examples, the BRAF structure (PDB ID: 3Q96) [ ] where SpacePAC identifies 3 mutational hotspots and the ALK structure (PDB ID: 2XBA) [ ] where SpacePAC identifies 2 mutational hotspots.

Techniques:

Results summary. A breakout of what biologically relevant regions are overlapped by the most significant cluster for each of the 18 proteins. Overall, 77% of the hotspots overlap a binding site or a protein domain.

Journal: BMC Bioinformatics

Article Title: A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

doi: 10.1186/1471-2105-15-231

Figure Lengend Snippet: Results summary. A breakout of what biologically relevant regions are overlapped by the most significant cluster for each of the 18 proteins. Overall, 77% of the hotspots overlap a binding site or a protein domain.

Article Snippet: To illustrate this point we consider two examples, the BRAF structure (PDB ID: 3Q96) [ ] where SpacePAC identifies 3 mutational hotspots and the ALK structure (PDB ID: 2XBA) [ ] where SpacePAC identifies 2 mutational hotspots.

Techniques: Binding Assay

Methodology comparison for BRAF

Journal: BMC Bioinformatics

Article Title: A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

doi: 10.1186/1471-2105-15-231

Figure Lengend Snippet: Methodology comparison for BRAF

Article Snippet: To illustrate this point we consider two examples, the BRAF structure (PDB ID: 3Q96) [ ] where SpacePAC identifies 3 mutational hotspots and the ALK structure (PDB ID: 2XBA) [ ] where SpacePAC identifies 2 mutational hotspots.

Techniques: Comparison